Author

Andreas Schweitzer

Universitätsmedizin Göttingen

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Molecular Biology· 1

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Approach:experimental assay· 1

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Eri SakataiD· 1 shared Jimena MuntaneriD· 1 shared Jorge CuéllariD· 1 shared José ValpuestaiD· 1 shared Margarita MenéndeziD· 1 shared Melissa Alonso· 1 shared Moisés Maestro-LópeziD· 1 shared Tat Cheung ChengiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperMolecular Biology

Eri SakataORCID

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1 paper

Recent·Most cited

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation

Moisés Maestro-López, Tat Cheung Cheng, Jimena Muntaner, Margarita Menéndez, Melissa Alonso, Andreas Schweitzer, Jorge Cuéllar, José Valpuesta, Eri Sakata

This study presents cryo-EM structures of the Bag1-bound 26S proteasome, revealing a mechanism for ubiquitin-independent proteasomal degradation through conformational changes in the 19S regulatory particle.

bioRxiv · Jan 22, 2025 · PreprintMolecular Biology