Author

José Valpuesta

Centro Nacional de BiotecnologíaORCID 0000-0001-7468-8053Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:experimental assay· 1

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Andreas Schweitzer· 1 shared Eri SakataiD· 1 shared Jimena MuntaneriD· 1 shared Jorge CuéllariD· 1 shared Margarita MenéndeziD· 1 shared Melissa Alonso· 1 shared Moisés Maestro-LópeziD· 1 shared Tat Cheung ChengiD· 1 shared

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1 shared paperMolecular Biology

Andreas Schweitzer

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintJan 22, 2025

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation

Moisés Maestro-López, Tat Cheung Cheng, Jimena Muntaner…·Eri Sakata

This study presents cryo-EM structures of the Bag1-bound 26S proteasome, revealing a mechanism for ubiquitin-independent proteasomal degradation through conformational changes in the 19S regulatory particle.

1 citation

experimental assay

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