Author

Tat Cheung Cheng

Universitätsmedizin GöttingenORCID 0000-0003-2801-3084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Eri SakataiD· 2 shared Andreas Schweitzer· 1 shared Anne K. SchütziD· 1 shared Antonia A. NemeciD· 1 shared Florian StengeliD· 1 shared Gregor WitteiD· 1 shared Jimena MuntaneriD· 1 shared Jorge CuéllariD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Eri SakataORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 4, 2026

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

Smruti Ranjan Rout, Martin Kulke, Maxim A. Droemer…·Eri Sakata

This study investigates how the p97/VCP mutation D395G increases redox sensitivity, leading to oxidative inactivation and contributing to neurodegeneration.

DOI 10.64898/2026.04.16.718620

statistical model

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJan 22, 2025

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation

Moisés Maestro-López, Tat Cheung Cheng, Jimena Muntaner…·Eri Sakata

This study presents cryo-EM structures of the Bag1-bound 26S proteasome, revealing a mechanism for ubiquitin-independent proteasomal degradation through conformational changes in the 19S regulatory particle.

1 citation

experimental assay

𝕏 PostBluesky