CAR T cell engineering impacts antigen-independent activation and co-inhibition
Simon Stücheli, Christoph Schultheiß, Paul Schmidt-Barbo, Andreas Zingg, Natascha Franz, Sarah Adamo, Claudia Fischer, Heinz Philipp Laubli, Mascha Binder
This study compares viral and non-viral methods for CAR T cell engineering, finding that non-viral SB transposition alters T cell activation and co-inhibition markers, with CAR design and donor type influencing outcomes.
bioRxiv · Jan 20, 2025 · PreprintImmunology