ImmunologybioRxivPreprint
CAR T cell engineering impacts antigen-independent activation and co-inhibition
Simon Stücheli, Christoph Schultheiß, Paul Schmidt-Barbo…·Mascha Binder
This study compares viral and non-viral methods for CAR T cell engineering, finding that non-viral SB transposition alters T cell activation and co-inhibition markers, with CAR design and donor type influencing outcomes.
DOI 10.1101/2025.01.20.631849