Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces
Atul M. Deshpande, Melanie Loth, Dimitrios N. Sidiropoulos, Shuming Zhang, Long Yuan, Alexander T.F. Bell, Qingfeng Zhu, Won Jin Ho, Cesar Augusto Santa-Maria, Daniele M. Gilkes, Stephen R. Williams, Cedric R. Uytingco, Jennifer G. Chew, Andrej Hartnett, Zachary Bent, , Elana Judith Fertig
This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.
Cell Systems · Apr 1, 2023Peer-reviewedBioinformatics