Jennifer G. Chew

Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.

Functional Inference of Gene Regulation using Single-Cell Multi-Omics

This paper develops FigR, a framework to integrate scATAC-seq and scRNA-seq data to infer gene regulatory networks and identify TF regulators in immune responses.

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

The paper maps spatial gene expression in the human dorsolateral prefrontal cortex using spatial transcriptomics and identifies layer-specific gene expression patterns linked to neuropsychiatric disorders.

Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development

The paper identifies brain-region specific splicing patterns at single-cell and spatial resolution in postnatal mice, revealing cell-type specific and region-specific isoform expression.

Droplet-based combinatorial indexing for massive scale single-cell epigenomics

The paper introduces a droplet-based combinatorial indexing method for high-throughput scATAC-seq, enabling large-scale single-cell chromatin accessibility profiling in mouse and human cells.