Author

Zachary Bent

10X Genomics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Jennifer G. Chew· 2 shared Joe Shuga· 2 shared Michael Schnall-Levin· 2 shared Rajiv Bharadwaj· 2 shared Stephen R. WilliamsiD· 2 shared Tobias D. Wheeler· 2 shared Adam FrankishiD· 1 shared Adam Weinstein· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBioinformatics

Jennifer G. Chew

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Author profile →

4 papers

Recent·Most cited

Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces

Atul M. Deshpande, Melanie Loth, Dimitrios N. Sidiropoulos, Shuming Zhang, Long Yuan, Alexander T.F. Bell, Qingfeng Zhu, Won Jin Ho, Cesar Augusto Santa-Maria, Daniele M. Gilkes, Stephen R. Williams, Cedric R. Uytingco, Jennifer G. Chew, Andrej Hartnett, Zachary Bent, , Elana Judith Fertig

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.

Cell Systems · Apr 1, 2023Peer-reviewedBioinformatics

Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development

Anoushka Joglekar, Andrey D. Prjibelski, Ahmed Essam Mahfouz, Paul G. Collier, Susan Lin, Anna Katharina Schlusche, Jordan Marrocco, Stephen R. Williams, Bettina Haase, Ashley Hayes, Jennifer G. Chew, Neil Weisenfeld, Man Ying Wong, Alexander N. Stein, Simon A. Hardwick, , Hagen Tilgner

The paper identifies brain-region specific splicing patterns at single-cell and spatial resolution in postnatal mice, revealing cell-type specific and region-specific isoform expression.

Nature Communications · Jan 19, 2021Peer-reviewedNeuroscience

Joint single cell DNA-Seq and RNA-Seq of gastric cancer reveals subclonal signatures of genomic instability and gene expression

Noemi Andor, Billy T. Lau, Claudia Catalanotti, Vijay Kumar, Anuja Sathe, Kamila Belhocine, Tobias D. Wheeler, Andrew D. Price, Maengseok Song, Željko Džakula, Jon M. Sorenson, David A. Stafford, Zachary Bent, Laura E. DeMare, Lance Hepler, , Hanlee P. Ji

The paper combines single cell DNA-Seq and RNA-Seq in gastric cancer to reveal subclonal genomic instability and gene expression patterns, showing evidence of tumor evolution.

bioRxiv · Jun 21, 2020 · PreprintGenomics

Massively parallel digital transcriptional profiling of single cells

Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Don A. Masquelier, , Jason H. Bielas

8-channel GemCode droplet barcoding captures ∼50% of loaded cells for 3′ mRNA counting, profiling 68k peripheral blood mononuclear cells and calling transplant chimerism from transcript variants.

Nature Communications · Jan 16, 2017Peer-reviewedGenomics✦ In-depth digest