Bile Acid Biosynthesis Avoiding Cholesterol
William J. Griffiths, Jonas Abdel-Khalik, Peter J. Crick, Eylan Yutuc, Michael Ogundare, Brian W. Bigger, Andrew A. Morris, Cedric H. Shackleton, Peter T. Clayton, Takashi Iida, Ria Sircar, Hanns-Ulrich Marschall, Jan Sjövall, Ingemar Björkhem, Rajat Rohatgi, Yuqin Wang
The paper identifies a novel bile acid biosynthesis pathway in Smith-Lemli-Opitz syndrome that bypasses cholesterol, starting from 7-dehydrocholesterol, and links intermediates to Hedgehog signaling.
bioRxiv · Aug 5, 2018 · PreprintBiochemistry