Author

Jonas Abdel-Khalik

Swansea UniversityORCID 0000-0002-6356-3682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 2 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Eylan YutuciD· 3 shared Yuqin WangiD· 3 shared Arunabha GhoshiD· 2 shared Mohsen Ali AsgariiD· 2 shared Peter J. CrickiD· 2 shared Simon Allan JonesiD· 2 shared William James GriffithsiD· 2 shared A. A. M. MorrisiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Eylan YutucORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJul 29, 2025

Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7alpha,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant

Eylan Yutuc, Arunabha Ghosh, Jonas Abdel-Khalik…·Yuqin Wang

This study shows that deleting CH25H and LIPA genes in humans eliminates 25-hydroxycholesterol but not 7alpha,25-dihydroxysterols, and increases cholesterol oxidation, which is partially reversed by hematopoietic stem cell transplant.

DOI 10.1101/2025.07.29.25330953

humanexperimental assay

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Genetic & Genomic MedicinemedRxivPreprintJun 23, 2025

Rare Cholesterol Related Disorders: A Sterolomic Library for Diagnosis and Monitoring of Diseases

Mohsen Ali Asgari, Eylan Yutuc, Jonas Abdel‐Khalik…·Yuqin Wang

The paper introduces a mass spectrometry sterolomic library to aid in diagnosing cholesterol-related inherited disorders by analyzing sterol profiles from 13 autosomal recessive disorders and predicting data for 8 more.

1 citation

humanmetabolomics

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BiochemistrybioRxivPreprintAug 5, 2018

Bile Acid Biosynthesis Avoiding Cholesterol

William J. Griffiths, Jonas Abdel-Khalik, Peter J. Crick…·Yuqin Wang

The paper identifies a novel bile acid biosynthesis pathway in Smith-Lemli-Opitz syndrome that bypasses cholesterol, starting from 7-dehydrocholesterol, and links intermediates to Hedgehog signaling.

DOI 10.1101/385419

humanmetabolomics

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