Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes
Naciye Magusali, Andrew C. Graham, Thomas M. Piers, Pantila Panichnantakul, Ümran Yaman, Maryam Shoai, Regina Hertfelder Reynolds, Juan Antonio Botía, Keeley J. Brookes, Tamar Guetta‐Baranes, Eftychia Bellou, Sevinç Bayram, Dimitra Sokolova, Mina Ryten, Carlo Sala Frigerio, , Dervis A. M. Salih
The paper identifies a genetic variant in OAS1 linked to increased Alzheimer's disease risk and severe COVID-19 outcomes, showing its role in microglial inflammation.
bioRxiv · Mar 16, 2021 · PreprintGenetics