Author

Sevinç Bayram

University College LondonORCID 0000-0002-5909-7391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Dervis A. M. SalihiD· 3 shared John HardyiD· 3 shared Juan Antonio BotíaiD· 3 shared Damian M. CummingsiD· 2 shared Eftychia BellouiD· 2 shared Frances A. EdwardsiD· 2 shared Jennifer M. PocockiD· 2 shared Keeley J. BrookesiD· 2 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Dervis A. M. SalihORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes

Naciye Magusali, Andrew C. Graham, Thomas M. Piers, Pantila Panichnantakul, Ümran Yaman, Maryam Shoai, Regina Hertfelder Reynolds, Juan Antonio Botía, Keeley J. Brookes, Tamar Guetta‐Baranes, Eftychia Bellou, Sevinç Bayram, Dimitra Sokolova, Mina Ryten, Carlo Sala Frigerio, , Dervis A. M. Salih

The paper identifies a genetic variant in OAS1 linked to increased Alzheimer's disease risk and severe COVID-19 outcomes, showing its role in microglial inflammation.

bioRxiv · Mar 16, 2021 · PreprintGenetics

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Wenfei Liu, Orjona Stella Taso, Rui Wang, Sevinç Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D. Andrews, Thomas M. Piers, Juan Antonio Botía, Jennifer M. Pocock, Damian M. Cummings, John Hardy, Frances A. Edwards, Dervis A. M. Salih

This study investigates how TREM2 influences microglial anti-inflammatory responses and shows that reduced TREM2 expression impairs anti-inflammatory gene expression and STAT6 levels.

Human Molecular Genetics · Sep 21, 2020Peer-reviewedNeuroscience

Genetic variability in response to Aβ deposition influences Alzheimer’s risk

Dervis A. M. Salih, Sevinç Bayram, Manuel Sebastian Guelfi, Regina Hertfelder Reynolds, Maryam Shoai, Mina Ryten, Jonathan Brenton, David Zhang, Mar Matarín, Juan Antonio Botía, Runil Shah, Keeley J. Brookes, Tamar Guetta‐Baranes, Kevin Morgan, Eftychia Bellou, , Valentina Escott‐Price

The paper identifies 5 new Alzheimer's risk loci by comparing mouse amyloid microglial response with human GWAS gene-based SNPs.

bioRxiv · Oct 8, 2018 · PreprintNeuroscience