Jennifer M. Pocock

Divergent consequences of PSEN1 knockout and PSEN2 knockout in stem cell derived models of the brain

This study compares the effects of PSEN1 and PSEN2 knockout in iPSC-derived brain cells, finding distinct impacts on endo-lysosomal systems and APP cleavage.

Microglia produce the amyloidogenic ABri peptide in familial British dementia

This study shows microglia produce ABri peptide in FBD, contributing to amyloid plaques and neurodegeneration, and suggests ITM2B/BRI2 is involved in microglial disease responses.

Amelioration of signalling deficits underlying metabolic shortfall in TREM2R47H human iPSC-derived microglia

This study investigates how metabolite supplementation affects metabolic and functional deficits in TREM2-mutant human iPSC-derived microglia, identifying distinct effects of citrate and succinate on mitochondrial function and phagocytosis.

Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.

The paper examines gene expression changes in microglia from LRRK2-WT and G2019S knock-in mice treated with zymosan and MLi-2, identifying differential expression patterns and potential PD-related pathways.

Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting neurons

The paper examines how TREM2 variants affect microglial exosomal proteomes and their functional impact on neurons.

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.

Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes

The paper identifies a genetic variant in OAS1 linked to increased Alzheimer's disease risk and severe COVID-19 outcomes, showing its role in microglial inflammation.

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

This study investigates how TREM2 influences microglial anti-inflammatory responses and shows that reduced TREM2 expression impairs anti-inflammatory gene expression and STAT6 levels.

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia

This study shows that TREM2 loss-of-function variants in human iPSC-derived microglia impair metabolic switching and PPARγ/p38MAPK signaling, affecting β-Amyloid phagocytosis.