Keeley J. Brookes

The paper examines age-related changes in tau and autophagy in cognitively normal individuals without neurodegeneration, finding reduced soluble tau and potential autophagy involvement.

The paper identifies DNA methylation signatures in Alzheimer's disease cortex, showing most changes are driven by non-neuronal cell types.

The paper identifies a genetic variant in OAS1 linked to increased Alzheimer's disease risk and severe COVID-19 outcomes, showing its role in microglial inflammation.

The paper develops a novel DNA methylation clock optimized for human cortex tissue, outperforming existing clocks and highlighting issues with previous associations between DNA methylation age and neurodegenerative phenotypes.

The paper identifies 5 new Alzheimer's risk loci by comparing mouse amyloid microglial response with human GWAS gene-based SNPs.

This study develops assays to genotype CR1-B allele and confirms its association with late-onset Alzheimer’s disease risk.