CD8α+ cells suppress SIV replication without evidence of viral immune escape during post treatment control
Ryan V. Moriarty, Olivia E. Harwood, Ethan P. Johnson, William Gardner, Corina C. Valencia, Andrew Conchas, Taina T. Immonen, Matthew R. Reynolds, Brandon F. Keele, Shelby L. O’Connor
This study shows CD8α+ cells suppress SIV replication without immune escape in post-treatment controllers, using a macaque model and barcoded viral sequencing.
bioRxiv · Nov 18, 2025 · PreprintMicrobiology