EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation
Yixiang Li, Yasmin Nabil Laimon, Hyeonseo Cho, Marina Vivero, Gabriel Roberti De Oliveira, Andrew Delcea, Varunika Savla, Yuting Chen, Yavuz T. Durmaz, Xintao Qiu, Shweta Kukreja, Rong Li, Talal El Zarif, Wesley S. Lu, McKayla Van Orden, , Matthew G. Oser
This study shows EED inactivation impairs SCLC tumorigenesis and drives LUAD-to-SCLC transformation, highlighting its role in maintaining SCLC neuroendocrine identity.
bioRxiv · Jul 7, 2025 · PreprintCancer Biology