Author

Varunika Savla

Brigham and Women's HospitalORCID 0009-0002-0281-5628Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Matthew G. OseriD· 2 shared Sabina SignorettiiD· 2 shared Yasmin Nabil LaimoniD· 2 shared Yavuz T. DurmaziD· 2 shared Alexander SpektoriD· 1 shared Andrew Delcea· 1 shared Andrew T. BockusiD· 1 shared Aniruddha SarkariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Matthew G. OserORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Thoracic OncologyPeer-reviewedAug 1, 2025

Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

Shilpa Singh, Catherine E. Gleason, Min Fang…·Matthew G. Oser

This paper develops cyclin A/B macrocyclic inhibitors that induce apoptosis in cancers with high E2F activity by blocking RxL-mediated interactions, showing efficacy in SCLC models.

29 citationstop 1%

humanproteomics

Cancer BiologybioRxivPreprintJul 7, 2025

EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation

Yixiang Li, Yasmin Nabil Laimon, Hyeonseo Cho…·Matthew G. Oser

This study shows EED inactivation impairs SCLC tumorigenesis and drives LUAD-to-SCLC transformation, highlighting its role in maintaining SCLC neuroendocrine identity.

2 citations

mousebulk RNA-seq