Conserved sequence elements in the final exon of MDM2-eight-exon skipping event reveal a cassette regulon model of alternative splicing controlled by a distal regulatory element.
Safiya Khurshid, Matías Montes, Rafia Rahat, Zac LaRocca-Stravalle, Whitney Jimenez, Andrew Goodwin, Claudia Kelly, Hannah Ackerman, Brad N. Bolon, Vincenzo Coppola, Dawn S. Chandler
The paper identifies a distal regulatory element controlling an eight-exon skipping event in MDM2, supporting a regulon model of alternative splicing in cancer.
bioRxiv · Feb 17, 2026 · PreprintMolecular Biology