Author

Safiya Khurshid

Nationwide Children's HospitalORCID 0000-0003-1620-3091Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 2

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dawn S. ChandleriD· 2 shared Abeba ZewduiD· 1 shared Andrew Goodwin· 1 shared Brad N. BoloniD· 1 shared Claudia Kelly· 1 shared Danielle BraggioiD· 1 shared David Koller· 1 shared David WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Dawn S. ChandlerORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 17, 2026

Conserved sequence elements in the final exon of MDM2-eight-exon skipping event reveal a cassette regulon model of alternative splicing controlled by a distal regulatory element.

Safiya Khurshid, Matías Montes, Rafia Rahat…·Dawn S. Chandler

The paper identifies a distal regulatory element controlling an eight-exon skipping event in MDM2, supporting a regulon model of alternative splicing in cancer.

DOI 10.64898/2026.02.14.705925

mousebulk RNA-seq

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Molecular BiologyPLoS ONEPeer-reviewedSep 17, 2025

Blockade of Interleukin-6 (IL-6) Signaling in Dedifferentiated Liposarcoma (DDLPS) Decreases Mouse Double Minute 2 (MDM2) Oncogenicity via Alternative Splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez…·Raphael E. Pollock

This study shows that blocking IL-6 signaling in DDLPS reduces MDM2 oncogenicity through alternative splicing, suggesting a potential therapeutic target.

2 citations

mousebulk RNA-seq

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