Author

Dawn S. Chandler

Nationwide Children's HospitalORCID 0000-0003-0670-9806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Safiya KhurshidiD· 2 shared Abeba ZewduiD· 1 shared Alexander S. BanksiD· 1 shared Amy WebbiD· 1 shared Andrew Goodwin· 1 shared Brad N. BoloniD· 1 shared Claire BryantiD· 1 shared Claudia Kelly· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Safiya KhurshidORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 17, 2026

Conserved sequence elements in the final exon of MDM2-eight-exon skipping event reveal a cassette regulon model of alternative splicing controlled by a distal regulatory element.

Safiya Khurshid, Matías Montes, Rafia Rahat…·Dawn S. Chandler

The paper identifies a distal regulatory element controlling an eight-exon skipping event in MDM2, supporting a regulon model of alternative splicing in cancer.

DOI 10.64898/2026.02.14.705925

mousebulk RNA-seq

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Molecular BiologyPLoS ONEPeer-reviewedSep 17, 2025

Blockade of Interleukin-6 (IL-6) Signaling in Dedifferentiated Liposarcoma (DDLPS) Decreases Mouse Double Minute 2 (MDM2) Oncogenicity via Alternative Splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez…·Raphael E. Pollock

This study shows that blocking IL-6 signaling in DDLPS reduces MDM2 oncogenicity through alternative splicing, suggesting a potential therapeutic target.

2 citations

mousebulk RNA-seq

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Molecular BiologyCellsPeer-reviewedNov 1, 2022

Alternatively Spliced Landscape of PPARγ mRNA in Podocytes is Distinct from Adipose Tissue

Claire Bryant, Amy Webb, Alexander S. Banks…·Shipra Agrawal

The paper identifies distinct PPARγ mRNA variants in podocytes compared to adipose tissue, highlighting differences in splicing patterns and regulatory mechanisms.

3 citations

humanbulk RNA-seq

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