Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences
Simeon D. Castle, Thea C T Irvine, Adrian Woolfson, Gregory Linshiz, Blake T. Riley, Ifor D. W. Samuel, Loren Picco, Philipp Holliger, Lauren M. Oldfield, Andrew Hessel, Thomas E. Gorochowski
This study investigates untemplated DNA synthesis by polymerases, showing that environmental conditions influence sequence composition and providing data for guided DNA synthesis.
Nature Communications · Feb 26, 2026Peer-reviewedSynthetic Biology