Author

Blake T. Riley

CUNY Advanced Science Research CenterORCID 0000-0003-2176-0503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. A. KeedyiD· 3 shared Ali EbrahimiD· 2 shared Shivani SharmaiD· 2 shared Adrian WoolfsoniD· 1 shared Akshay RajuiD· 1 shared Aliki PerdikariiD· 1 shared Andrew Hessel· 1 shared Anthony C. BishopiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

D. A. KeedyORCID

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4 papers

Recent·Most cited

Synthetic BiologyNature CommunicationsPeer-reviewedFeb 26, 2026

Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences

Simeon D. Castle, Thea C T Irvine, Adrian Woolfson…·Thomas E. Gorochowski

This study investigates untemplated DNA synthesis by polymerases, showing that environmental conditions influence sequence composition and providing data for guided DNA synthesis.

2 citations

long-read sequencingexperimental assay

𝕏 PostBluesky

BiophysicsJournal of Biological ChemistryPeer-reviewedOct 23, 2025

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

Aliki Perdikari, Virgil A. Woods, Ali Ebrahim…·D. A. Keedy

The paper identifies functional PTP1B variants in thin individuals and uses structural biology to reveal allosteric sites for obesity drug development.

8 citations

humanprotein structure

𝕏 PostBluesky

BiophysicsProteins Structure Function and BioinformaticsPeer-reviewedJul 5, 2025

Three STEPs forward: A trio of unexpected structures of PTPN5

Liliana Guerrero, Ali Ebrahim, Blake T. Riley…·D.A. Keedy

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

2 citations

structural biologyexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 23, 2025

Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

Akshay Raju, Shivani Sharma, Blake T. Riley…·D.A. Keedy

The paper develops RINFAIRE to analyze multiconformer models of PTPs, revealing shared and unique allosteric networks and validating their functional impact through mutations.

5 citations

protein structuredeep learning

𝕏 PostBluesky