The Elevated Expression of ORF75, a Lytic KSHV Gene, in Kaposi Sarcoma Lesions is Driven by a GC-rich DNA cis Element in its Promoter Region
Ashwin Nair, David A. Davis, Andrew Warner, Baktiar O. Karim, Ramya Ramaswami, Robert Yarchoan
This study identifies a GC-rich cis element in the ORF75 promoter of KSHV that drives its constitutive expression in endothelial and epithelial cells, contributing to its high expression in Kaposi sarcoma lesions.
PLoS Pathogens · Mar 17, 2025Peer-reviewedMicrobiology