Baktiar O. Karim

A simple circuit to sustain intact tumor microenvironments for complex drug interrogations

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

Id1 Promotes Clonal Hematopoiesis in Mice with Tet2 Loss of Function

Genetic ablation of Id1 in Tet2-/- mice reduces clonal hematopoiesis by increasing CDKI expression, apoptosis, senescence, and differentiation while decreasing cell growth.

Angulin-1/LSR inhibition transiently disrupts the blood-tumor barrier to enhance doxil permeability and impair malignant glioma progression

The paper investigates how Angubindin-1 disrupts the blood-tumor barrier by targeting Angulin-1/LSR, enhancing drug permeability and reducing glioma progression.

The Elevated Expression of ORF75, a Lytic KSHV Gene, in Kaposi Sarcoma Lesions is Driven by a GC-rich DNA cis Element in its Promoter Region

This study identifies a GC-rich cis element in the ORF75 promoter of KSHV that drives its constitutive expression in endothelial and epithelial cells, contributing to its high expression in Kaposi sarcoma lesions.

SRSF3 is oncogenic in breast but tumor-suppressive in liver by differential regulation of gene expression

This study shows SRSF3 is oncogenic in breast cancer and tumor-suppressive in liver cancer through context-dependent gene regulation.

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth

This study identifies LZK as a therapeutic target in HNSCC by showing its regulation of c-MYC and GOF p53, and demonstrates PROTAC-mediated degradation as a potential treatment.