Robert Yarchoan

This study establishes patient-derived KS xenografts that maintain KSHV infection and recapitulate KS tumor gene signatures, enabling analysis of tumor microenvironment cell communications.

This study identifies K5 as a KSHV protein cleaved by caspases during lytic replication, which helps protect infected cells from apoptosis.

This study identifies a GC-rich cis element in the ORF75 promoter of KSHV that drives its constitutive expression in endothelial and epithelial cells, contributing to its high expression in Kaposi sarcoma lesions.