Loss-of-function of ALDH3B2 transdifferentiates human pancreatic duct cells into beta-like cells
Jian Li, Kevin Bode, Yu‐Chi Lee, Noelle Morrow, Andy Ma, Siying Wei, Jessica da Silva Pereira, Taylor Stewart, Alexander Lee-Papastavros, Jennifer Hollister‐Lock, Brooke Sullivan, Susan Bonner‐Weir, Yi Peng
This study shows that knocking out ALDH3B2 in human pancreatic duct cells converts them into beta-like cells that function and reduce blood glucose in mice.
bioRxiv · May 13, 2024 · PreprintGenetics