Inhibition of mTORC1 by rapamycin results in feedback activation of Akt S473 and aggravates hallmarks of osteoarthritis in female mice and non-human primates
Dennis M. Minton, Aditya R. Ailiani, Michael D.K. Focht, Mariana E. Kersh, Amy Li, Christian J. Elliehausen, Michelle M. Sonsalla, Dudley W. Lamming, Angela J. Marolf, Kelly S Santangelo, Adam B. Salmon, Adam R. Konopka
This study shows that rapamycin inhibits mTORC1 and activates AktS473 in joint tissues, leading to worsened osteoarthritis in female mice and marmosets.
bioRxiv · May 14, 2024 · PreprintPhysiology