Adam B. Salmon

Aging Leads to Altered Physiological Reactivity in Response to Repeated Social Separation Stress in a Nonhuman Primate Model

This study examines how aging affects physiological reactivity to social stress in marmosets, finding differences in HPA activity, metabolic markers, and social behavior between peri-geri and very-geri females and males.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed

This study finds that aging baboons show sex-specific declines in prefrontal cortex mitochondrial bioenergetics, with males experiencing greater ETC activity loss and a link between walking speed and respiration in males.

Inhibition of mTORC1 by rapamycin results in feedback activation of Akt S473 and aggravates hallmarks of osteoarthritis in female mice and non-human primates

This study shows that rapamycin inhibits mTORC1 and activates AktS473 in joint tissues, leading to worsened osteoarthritis in female mice and marmosets.

Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring.

This study examines the effects of maternal undernutrition on hepatic mitochondrial function in baboon offspring during aging, finding male-specific increases in mitochondrial bioenergetics without changes in plasma metabolites.

Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets

This study examines sensory nerve types innervating masticatory muscles in common marmosets, finding distinct innervation patterns with differences in fiber types across muscle groups.

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate slows aging in mice

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.

DNA methylation age analysis of rapamycin in common marmosets

This paper develops epigenetic clocks for common marmosets using DNA methylation data and tests rapamycin's effect on epigenetic age, finding no significant impact.

Pan-primate DNA methylation clocks

This study develops pan-primate epigenetic clocks and sex predictors using DNA methylation data from 37 primate species, achieving high accuracy for age estimation across species.