Author

Michael D.K. Focht

University of Illinois Urbana-ChampaignORCID 0000-0002-8451-496XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:multiome· 1 Organism:non-human primate· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

Mariana E. KershiD· 2 shared Adam B. SalmoniD· 1 shared Adam R. KonopkaiD· 1 shared Aditya R. Ailiani· 1 shared Advait BoroleiD· 1 shared Amir Ostadi MoghaddamiD· 1 shared Amy J. Wagoner JohnsoniD· 1 shared Amy Li· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Mariana E. KershORCID

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2 papers

Recent·Most cited

The effect of microstructural variations in tendon and ligament on diffusion tensor MRI

Michael D.K. Focht, Advait Borole, Amir Ostadi Moghaddam, Amy J. Wagoner Johnson, Roberto Alonso Pineda Guzman, Bruce M. Damon, Noel M. Naughton, Mariana E. Kersh

This study investigates how microstructural variations in tendon and ligament affect diffusion tensor MRI metrics through simulations of fiber networks.

bioRxiv · Mar 16, 2026 · PreprintBioengineering

Inhibition of mTORC1 by rapamycin results in feedback activation of Akt S473 and aggravates hallmarks of osteoarthritis in female mice and non-human primates

Dennis M. Minton, Aditya R. Ailiani, Michael D.K. Focht, Mariana E. Kersh, Amy Li, Christian J. Elliehausen, Michelle M. Sonsalla, Dudley W. Lamming, Angela J. Marolf, Kelly S Santangelo, Adam B. Salmon, Adam R. Konopka

This study shows that rapamycin inhibits mTORC1 and activates AktS473 in joint tissues, leading to worsened osteoarthritis in female mice and marmosets.

bioRxiv · May 14, 2024 · PreprintPhysiology