Immunizing small cell lung cancer mice with isoaspartylated Elavl4 after chemotherapy mimics improved survival of anti-ELAVL4 antibody-positive small cell lung cancer patients
Diego Alejandro Velarde, Joseph Valdes, Hannah Lee, Chunli Yan, Sarah Elmalh, Angie Moreno, Daniel J. Mullen, Matthew A. Gladstone, Sanika Gulivani, Qi Nie, Ming Li, W. Martin Kast, Ite A. Laird‐Offringa
This study shows that immunizing SCLC mice with isoaspartylated Elavl4 after chemotherapy improves survival, mirroring the benefit seen in patients with anti-ELAVL4 antibodies.
bioRxiv · Sep 1, 2026 · PreprintCancer Biology