The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states
Dalya Rosner, Jiahong Sun, Rita Cacace, Angie Yee, Chaitanya Wagh, Anna Rychkova, Mariah Dunlap, Daniel R. Gulbranson, Adiljan Ibrahim, Xiaoting Wang, Rebecca Y. Wang, Alice Buonfiglioli, Muhammad Alhawagri, Philip L. Kong, Marina K. Roell, , Arnon Rosenthal
This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.
Neuron · Dec 22, 2025Peer-reviewedNeuroscience