Daniel R. Gulbranson

This study shows that Parkin deficiency alters genetic dependencies for neuronal survival, identifying key pathways and genes involved in this rewiring.

X-Cell predicts causal perturbation responses across diverse cellular contexts using a diffusion language model trained on a large CRISPRi Perturb-seq dataset.

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.