Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect
Matthew R. Dent, Anthony W. DeMartino, Qinzi Xu, Xiukai Chen, Alay Gandhi, Hyon S. Hwang, Kaitlin A. Bocian, Jacob E. Correnti, Youmna Abdelghany, Elmira Alipour, Kamil B. Ucer, Stephen R. Baker, Ajay Ram Srimath Kandada, Angka Bulbul, Daniel B. Kim‐Shapiro, , Mark T. Gladwin
This paper develops a hemoprotein-based CO scavenger that selectively removes CO from hemoglobin, accelerates its clearance, and avoids hypertension compared to hemoglobin-based treatments.
Proceedings of the National Academy of Sciences · Aug 5, 2025Peer-reviewedBiochemistry