Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
Sven Turkalj, Bilyana Stoilova, Angus Groom, Felix A. Radtke, Rabea Mecklenbrauck, Niels Asger Jakobsen, Curtis Andrew Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin‐Peek, Verena Körber, Farhad Ravandi, , Paresh Vyas
This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.
Blood · Nov 5, 2025Peer-reviewedCancer Biology