Niels Asger Jakobsen

Deep learning enables cross-species annotation and attribution of ageing states in haematopoietic stem and immune cells

The paper develops a cross-species deep learning framework to annotate and attribute ageing states in haematopoietic stem and immune cells, achieving high AUROC scores in human data.

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.