Author

Ghayas C. Issa

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-4339-8683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessandro Pinto· 1 shared Angus Groom· 1 shared Anne P. de GrootiD· 1 shared Aziz FarhatiD· 1 shared Batchimeg UsukhbayariD· 1 shared Bilyana StoilovaiD· 1 shared Bonnie WangiD· 1 shared Cheng ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioengineering

Alessandro Pinto

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Scaling Multiplex qPCR Primer Design to 1000-plex using the Degenerate Incomplete Multiplex Primer List Extension (DIMPLE) Algorithm

Alessandro Pinto, Xue Dong, Wei Wu, Sara J. Johnson, Qin Wen, Cheng Zhang, Jana Havey, Bonnie Wang, Guilin Tang, Aziz Farhat, David Yu Zhang, Ghayas C. Issa, Xi Zhang

The paper introduces DIMPLE, a scalable qPCR primer design algorithm that enables 10,000+ primers in a single reaction, achieving low VAF detection and multiplex applications.

bioRxiv · Apr 21, 2026 · PreprintBioengineering

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

Sven Turkalj, Bilyana Stoilova, Angus Groom, Felix A. Radtke, Rabea Mecklenbrauck, Niels Asger Jakobsen, Curtis Andrew Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin‐Peek, Verena Körber, Farhad Ravandi, , Paresh Vyas

This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.

Blood · Nov 5, 2025Peer-reviewedCancer Biology