Verena Körber

LACHESIS infers evolutionary trajectories of malignant transformation from whole-genome sequencing data and provides risk stratification for childhood and adult cancers.

This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

The paper investigates NSPC proliferation dynamics in a mouse model, finding that adaptive clonal expansion by a small fraction of NSPCs can regenerate the entire neuronal population.