Disordered regions of human eIF4B orchestrate a dynamic self-association landscape
Bikash Chandra Swain, Pascale Sarkis, Vanessa Ung, Sabrina Rousseau, Laurent Fernandez, Ani Meltonyan, V. Esperance Aho, Davide Mercadante, Cameron D. Mackereth, Mikayel G. Aznauryan
This study investigates the dynamic self-association of eIF4B's intrinsically disordered region using experiments and simulations, revealing its role in forming oligomers and phase separation.
Nature Communications · Oct 9, 2024Peer-reviewedBiophysics