Cameron D. Mackereth

Unconventional DNA architecture in a dopamine-bound aptamer complex

This study determines the structure of a dopamine-binding DNA aptamer using NMR, revealing an unconventional DNA fold distinct from typical DNA structures and providing insights into its specificity and potential applications in biosensor design.

Regulation of cell proliferation by a novel feedback system on Cdk function

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers

Structure providers for 18 CASP16 nucleic acid targets find blind predictions capture secondary structure but miss non-canonical interactions, backbone kinks, ligand sites, and intermolecular interfaces.

Paralog-specific intrabodies for PSD-93 and SAP102 expand the molecular toolkit to resolve excitatory synapse organization

The paper develops paralog-specific intrabodies for PSD-93 and SAP102 to study excitatory synapse organization.

Helical foldamers as selective G-quadruplex ligands

This study identifies helical foldamers with quinoline and pyridine units as selective G-quadruplex ligands, showing preference for parallel structures and sequence variants.

Disordered regions of human eIF4B orchestrate a dynamic self-association landscape

This study investigates the dynamic self-association of eIF4B's intrinsically disordered region using experiments and simulations, revealing its role in forming oligomers and phase separation.

Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes

The paper develops synthetic binders specific to PSD-95 for imaging endogenous proteins with minimal impact on function and compatibility with super-resolution techniques.

Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function

The paper analyzes 184 octocoral mitochondrial genomes to study mt-mutS evolution and function, finding evidence for its role in DNA repair and its impact on sequence evolution rates.

Structural basis of UCUU RNA motif recognition by splicing factor RBM20

This paper determines the structure of the RBM20 RRM domain bound to UCUU RNA, revealing a coupled folding-binding mechanism for motif recognition.