Structural basis of epitope recognition by anti-alpha synuclein antibodies MJFR14-6-4-2
I. Lieknina, Lasse Reimer, Teodors Panteļejevs, Alons Lends, Kristaps Jaudzems, Aadil El-Turabi, Hjalte Gram, Anissa Hammi, Poul Henning Jensen, Kaspars Tārs
The paper investigates how the antibody MJFR14-6-4-2 recognizes aggregated alpha-synuclein and shows that epitope masking and epitope concentration drive its selectivity for different aggregates.
npj Parkinson s Disease · Oct 27, 2024Peer-reviewedNeuroscience