Kristaps Jaudzems

This study shows that loss of PARP7 in pancreatic cancer cells increases type I interferon signaling and enhances immune cell infiltration, leading to reduced tumor growth.

The paper investigates how the antibody MJFR14-6-4-2 recognizes aggregated alpha-synuclein and shows that epitope masking and epitope concentration drive its selectivity for different aggregates.

The paper designs and tests novel covalent inhibitors targeting CAIX, achieving high affinity and selectivity for cancer treatment.