NF-κB mediates transactivation of HNRNPD, resulting in PTEN destabilization and constitutive activation of the PI3K-AKT pathway in oral cancer cells
Vikas Kumar, Anjani Mittal, Anurag Kumar, Moien Rasheed Lone, Vandana Yadav, Priya Verma, Dibyabhaba Pradhan, Deepika Mishra, Alok Thakar, Shyam Singh Chauhan
This study shows hnRNPD, upregulated by NF-κB, destabilizes PTEN mRNA, activates PI3K-AKT pathway, and promotes oral cancer cell proliferation, migration, and survival.
bioRxiv · Jan 5, 2025 · PreprintCancer Biology