A novel xenograft model reveals invasive mesenchymal transition and ineffective angiogenic response during anti-angiogenic therapy resistance
Arman Jahangiri, William Chen, Ankush Chandra, Alan Nguyen, Garima Yagnik, Jacob Weiss, Kayla J. Wolf, Jung-Ming G. Lin, Soeren Mueller, Jonathan Rick, Maxim Sidorov, Patrick Flanigan, W. Shawn Carbonell, Aaron Diaz, Luke Gilbert, , Manish K. Aghi
This study develops a xenograft model to study bevacizumab resistance in glioblastoma, finding increased mesenchymal markers and ineffective angiogenic responses across generations.
bioRxiv · Apr 12, 2018 · PreprintCancer Biology