Manish K. Aghi

Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma

This paper demonstrates that a viral vector delivering an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma models.

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum

This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.

Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells

The paper identifies ACP1 and AURKB as regulators of cortactin-driven actin remodeling in glioblastoma invasion using CRISPRi screens in 3D hydrogels.

Human precentral gyrus neurons link speech sequences from listening to speaking

The paper investigates neural activity in the human precentral gyrus during speech tasks, finding neurons that encode both listening and speaking phases, including mirror and bridge neurons.

Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

Dynamic fibroblast-immune interactions shape wound healing after brain injury

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

A novel xenograft model reveals invasive mesenchymal transition and ineffective angiogenic response during anti-angiogenic therapy resistance

This study develops a xenograft model to study bevacizumab resistance in glioblastoma, finding increased mesenchymal markers and ineffective angiogenic responses across generations.