Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma
Chiung-Ying Chang, Zohar Shipony, Sherry G. Lin, Ann Kuo, Xiaochen Xiong, Kyle M. Loh, William James Greenleaf, Gerald R. Crabtree
This study shows that increased ACTL6A occupancy in BAF chromatin remodelers drives SCC initiation by enhancing TEAD-YAP binding and counteracting polycomb repression.
Molecular Cell · Oct 22, 2021Peer-reviewedMolecular Biology