Zohar Shipony

This study evaluates ultra-high-depth RNA-seq for Mendelian disorder diagnostics, showing improved detection of low-abundance transcripts and splicing variants, and introduces a resource to guide sequencing depth selection.

The paper investigates how extrachromosomal DNA (ecDNA) inheritance mechanisms influence cancer evolution through mitotic segregation and micronuclei formation.

The paper develops RoboATAC, an automated ATAC-seq method, to study how TF dosage affects chromatin accessibility and gene expression, finding that DNA sequence predicts dosage sensitivity and nucleosome positioning patterns vary by TF.

The paper introduces sciMETv3, a high-throughput single-cell DNA methylation profiling method, achieving 100-fold higher cell throughput and compatibility with multimodal assays.

This study shows that early colorectal cancer loses promoter-enhancer connectivity, leading to gene expression changes and a two-phase model of transcriptional regulation.

The paper characterizes age-related and inter-individual variation in circulating hematopoietic stem cells and establishes a normal reference to identify hematological disorders.

The paper uses ultra high-throughput methylation sequencing to study DNA methylation changes during colorectal cancer progression from normal tissue to adenocarcinoma.

This study shows that increased ACTL6A occupancy in BAF chromatin remodelers drives SCC initiation by enhancing TEAD-YAP binding and counteracting polycomb repression.

The paper uses single-cell transcriptomics and epigenomics to analyze immune cell subsets in human tonsils, revealing that autoimmune risk variants have strong regulatory potential in germinal center cells.

This paper introduces SMAC-seq, a method for long-range chromatin accessibility mapping in eukaryotes, and demonstrates its application in yeast.