Kyle M. Loh

The paper maps gene regulators of endothelial cell differentiation using CRISPR and single-cell RNA-seq, identifying Hippo mechanosignaling as critical for endothelial identity.

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

The paper uses sequential CRISPR activation screens to identify genes sufficient for viral entry into cells, demonstrating effectiveness with Ebola and rabies viruses.

This study shows DNMT3AR882H mutations are not required for maintaining AML but are linked to higher leukemia stem cell frequency.

The paper identifies that neonatal vascularization, specifically angiogenesis in the hepatic vein periphery, determines adult liver size in mice by adding lobules.

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

This study develops iPSC-derived T cells targeting the EGFR C797S mutation in NSCLC, showing their ability to recognize and kill cancer cells expressing this mutation.

This study uses metabolically purified human hepatocytes to show that Ebola and Lassa viruses have distinct effects on liver cells.

The paper reveals that pioneer transcription factors use mesoscale chromatin confinement to efficiently search for and bind to closed chromatin regions in live cells.

This study identifies TMX1 as a critical regulator of T cell function by modulating CD3zeta stability and TCR signaling.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study shows that increased ACTL6A occupancy in BAF chromatin remodelers drives SCC initiation by enhancing TEAD-YAP binding and counteracting polycomb repression.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.

The paper generates 65 hiPSC clones with 16p11.2 CNVs and identifies transcriptional changes in neural development using RNA-Seq.

This paper demonstrates that chimpanzee iPSCs can form cross-species chimeras with rhesus macaque embryos, suggesting functional similarity between human and chimpanzee cells.

This study accelerates the generation of human liver progenitors from pluripotent stem cells by blocking unwanted lineage formation and manipulating temporal signals.