Menaquinone depletion resensitises bedaquiline-resistant tuberculosis
Jennefer Wetzel, John Dallow, Ellie Davis, William H. Pearson, Stijn Daems, Matthias Govaerts, Joyce Hereijgers, Joke Sprangers, Barry E. Truebody, Valérie Maes, Vera van Hasselt, Annelies Leemans, Venugopal Pujari, Ann Vos, Carlos M Martinez Viturro, , Anil Koul
This study identifies MenG inhibitors that restore bedaquiline susceptibility in resistant tuberculosis strains through menaquinone pathway disruption.
bioRxiv · Feb 10, 2026 · PreprintMicrobiology