Alexander S. Pym

This study identifies MenG inhibitors that restore bedaquiline susceptibility in resistant tuberculosis strains through menaquinone pathway disruption.

The paper identifies pre-existing bedaquiline resistance variants in Mycobacterium tuberculosis genomes before clinical use of the drug, highlighting the need for rapid susceptibility testing.

The paper investigates NAT2 polymorphisms and their effect on isoniazid pharmacokinetics in HIV-infected South Africans with tuberculosis, finding no significant genotype-phenotype correlation.

This study compares whole genome sequencing of Mycobacterium tuberculosis directly from sputum to sequencing from culture, finding greater genetic diversity in sputum-derived samples.