The DNA damage response regulates the oocyte pool in mammals
Ana Martínez-Marchal, Maria Teresa Guillot, Mònica Ferrer‐Roda, Anna Guixé, Montserrat Garcia-Caldés, Ignasi Roig
This study shows that the DNA damage response, specifically CHK2, regulates oocyte elimination and follicle formation in mammals by controlling meiotic recombination and cyst breakdown.
bioRxiv · Oct 24, 2019 · PreprintDevelopmental Biology